Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells
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چکیده
منابع مشابه
Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells☆
Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor in adults. Current therapy includes surgery, radiation and chemotherapy with temozolomide (TMZ). Major determinants of clinical response to TMZ include methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter and mismatch repair (MMR) status. Though the MGMT promoter is methylated in 45% of cases, f...
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ژورنال
عنوان ژورنال: Journal of Biomedical Research
سال: 2010
ISSN: 1674-8301
DOI: 10.1016/s1674-8301(10)60057-7